Validation of Academic Research Consortium for High Bleeding Risk Definition in East-Asian Patients
Jinho Lee1, Hoyun Kim1, Yeonwoo Choi1, Do-Yoon Kang1, Jung-Min Ahn1, Seung-Jung Park1, Duk-Woo Park1
Asan Medical Center, Korea (Republic of)1
Clinical applicability of the Academic Research Consortium High Bleeding Risk (ARC-HBR)criteria in East-Asian patients receiving potent antiplatelet therapy for acutecoronary syndromes (ACS) is still undetermined.
We analyzed data from the TICAKOREA trial, randomly assigned 800 Korean ACS subjects to receive, in a 1:1 ratio, ticagrelor or clopidogrel. Patients were considered HBR if they met at least one major or two minor ARC-HBR criteria. The primary bleeding endpoint was Bleeding Academic Research Consortium (BARC) 3 or 5 bleeding and the primary ischemic endpoint was a major adverse cardiovascular event (MACE; a composite of cardiovascular death, myocardial infarction, or stroke) at 12 months.
This study validates the ARC-HBR definition in Korean ACS patients. Approximately 15% of patients qualified as HBR patients who were at increased risk not only for bleeding but also for thrombotic events.The clinical application of ARC-HBR to determine the relative effect of different antiplatelet regiments should be further investigated