E-Abstract

JACC

Lots of interesting abstracts and cases were submitted for TCTAP 2023. Below are the accepted ones after a thorough review by our official reviewers. Don’t miss the opportunity to expand your knowledge and interact with authors as well as virtual participants by sharing your opinion in the comment section!

TCTAP A-004

Long-Term Prognostic Impact of Fractional Flow Reserve After Coronary Stenting: Insights From the Internation Post-PCI FFR Extended Registry

By Bon-Kwon Koo, Doyeon Hwang, Jaewook Chung, Joo Myung Lee, Hyunjong Lee, Chang-Wook Nam, Eun-Seok Shin, Joon-Hyung Doh, Akiko Matsuo, Hitoshi Matsuo, Shao-Liang Chen,

Presenter

Bon-Kwon Koo

Authors

Bon-Kwon Koo1, Doyeon Hwang1, Jaewook Chung1, Joo Myung Lee2, Hyunjong Lee3, Chang-Wook Nam4, Eun-Seok Shin5, Joon-Hyung Doh6, Akiko Matsuo7, Hitoshi Matsuo8, Shao-Liang Chen9, 10

Affiliation

Seoul National University Hospital, Korea (Republic of)1, Samsung Medical Center, Korea (Republic of)2, Sejong General Hospital, Korea (Republic of)3, Keimyung University Dongsan Hospital, Korea (Republic of)4, Ulsan University Hospital, Korea (Republic of)5, Inje University Ilsan Paik Hospital, Korea (Republic of)6, Kyoto Second Red Cross Hospital, Japan7, Gifu Heart Center, Japan8, Nanjing First Hospital of Nanjing Medical University, China9, Tsuchiura Kyodo General Hospital, Japan10
View Study Report
TCTAP A-004
Physiologic Lesion Assessment

Long-Term Prognostic Impact of Fractional Flow Reserve After Coronary Stenting: Insights From the Internation Post-PCI FFR Extended Registry

Bon-Kwon Koo1, Doyeon Hwang1, Jaewook Chung1, Joo Myung Lee2, Hyunjong Lee3, Chang-Wook Nam4, Eun-Seok Shin5, Joon-Hyung Doh6, Akiko Matsuo7, Hitoshi Matsuo8, Shao-Liang Chen9, 10

Seoul National University Hospital, Korea (Republic of)1, Samsung Medical Center, Korea (Republic of)2, Sejong General Hospital, Korea (Republic of)3, Keimyung University Dongsan Hospital, Korea (Republic of)4, Ulsan University Hospital, Korea (Republic of)5, Inje University Ilsan Paik Hospital, Korea (Republic of)6, Kyoto Second Red Cross Hospital, Japan7, Gifu Heart Center, Japan8, Nanjing First Hospital of Nanjing Medical University, China9, Tsuchiura Kyodo General Hospital, Japan10

Background

Fractional flowreserve (FFR) after percutaneous coronary intervention (PCI) reflects thedegree of maximal flow reduction by residual disease after PCI. The clinicalrelevance of post-PCI FFR is well known, but its long-term prognostic impact isstill unclear.

Methods

A total of 2,128patients who underwent drug-eluting stent implantation and post-PCI FFRmeasurement with 5-year outcome data were analyzed. The primary outcome wastarget vessel failure (TVF) at 5 years, a composite of cardiac death, targetvessel myocardial infarction (TVMI), and target vessel revascularization (TVR).The secondary outcome was a composite of cardiac death or TVMI and individualoutcomes at 5 years. 

Results

During 5 years of follow-up,the cumulative incidence of TVF was 12.0%, and that of cardiac death of TVMIwas 3.5%. The Median (IQR) post-PCI FFR of the target vessel was 0.88(0.84-0.93). The risk of TVF increased along with the decrease of post-PCI FFR(adjusted hazard ratio [HR] per 0.01 FFR decrease 1.044, 95% confidenceinterval [CI] 1.025-1.063, p-value<0.001). This significant inverseassociation was also observed regarding a composite of cardiac death or TVMI(adjusted HR per 0.01 FFR decrease 1.042, 95% CI 1.006-1.080,p-value=0.023).The risk of TVR was also significantly associated with post-PCIFFR values inrevascularization in stented segments (adjusted HR per 0.01 FFR decrease 1.036,95% CI 1.010-1.063, p-value=0.007) and non-stented segments (adjusted HR per0.01 FFR decrease 1.054, 95% CI 1.023-1.087, p-value<0.001). 


Conclusion

The long-term outcome results of the Internation Post-PCI FFR Extendedregistry showed that the prognostic impact of post-PCI FFR is maintained until5 years of follow-up, and post-PCI FFR is associated with target vessel-relatedevents, including cardiac death or TVMI. 

Leave Comments