E-Abstract

JACC

Lots of interesting abstracts and cases were submitted for TCTAP 2023. Below are the accepted ones after a thorough review by our official reviewers. Don’t miss the opportunity to expand your knowledge and interact with authors as well as virtual participants by sharing your opinion in the comment section!

TCTAP A-013

Association of Cardiovascular Events and Long-Term Exposure to Fine Particulate Matter Among Survivors of ST-Elevation Myocardial Infarction Who Received Percutaneous Coronary Intervention

By Teeranan Angkananard, Phannita Piriyavirut, Phattarawadee Mathupayas, Naravit Kowathanakul, Bulakorn Thawornrunggit, Thiris Laohapornsvan, Arthit Vongsaosup, Nattapun Rattanajaruskul, Orrawan Wansawad, Worawut Roongsangmanoon

Presenter

Teeranan Angkananard

Authors

Teeranan Angkananard1, Phannita Piriyavirut1, Phattarawadee Mathupayas1, Naravit Kowathanakul1, Bulakorn Thawornrunggit1, Thiris Laohapornsvan1, Arthit Vongsaosup2, Nattapun Rattanajaruskul1, Orrawan Wansawad2, Worawut Roongsangmanoon1

Affiliation

Srinakharinwirot University, Thailand1, HRH Princess Maha Chakri Sirindhorn Medical Center, Thailand2
View Study Report
TCTAP A-013
Acute Coronary Syndromes (STEMI, NSTE-ACS)

Association of Cardiovascular Events and Long-Term Exposure to Fine Particulate Matter Among Survivors of ST-Elevation Myocardial Infarction Who Received Percutaneous Coronary Intervention

Teeranan Angkananard1, Phannita Piriyavirut1, Phattarawadee Mathupayas1, Naravit Kowathanakul1, Bulakorn Thawornrunggit1, Thiris Laohapornsvan1, Arthit Vongsaosup2, Nattapun Rattanajaruskul1, Orrawan Wansawad2, Worawut Roongsangmanoon1

Srinakharinwirot University, Thailand1, HRH Princess Maha Chakri Sirindhorn Medical Center, Thailand2

Background

A short-term exposure to fine particulate matter [≤ 2.5 μm in aerodynamic diameter (PM2.5)]-related risk of ST-elevation myocardial infarction (STEMI) events were investigated by a few studies. Little is known, however, about the influence of long-term exposure to PM2.5 on the risk of cardiovascular events (CVE) among survivors from STEMI who received percutaneous coronary intervention (PCI).

Methods

Totally 163 Thai patients with STEMI who receiving PCI between May 2018 and July 2019 were enrolled. Cumulative ground-level concentrations of the mean annual concentration of PM2.5 were acquired from satellite observations of aerosol optical depth based on subjects’ annual habitations during one-year follow-up.  Standard Cox proportional hazard model was applied and adjusted for potential confounders. An analysis of the mean of PM2.5 1 year after STEMI events was performed by dividing mean PM2.5 into 3 groups; <6.6 µg/ m3 (reference), 6.6 to 8.0 µg/ m3 and > 8.0 µg/ m3.

Results

The majority of cases were men (76.7%) with an overall average age being at 58.9±13.2 years. Mean annual concentration of PM2.5 was 7.41±1.7µg/m3. Up to the end of follow-up, 30(18.4%) had CVE with higher mean annual PM2.5 concentration (8.3±2.2 vs. 7.2±1.5 µg/m3). Using standard Cox models, the CVE rates were higher for individuals exposed to higher levels of PM2.5 with adjusted hazard ratio (HR) 1.26 (95% CI, 1.04-1.53).This association was still significant with exposures to PM2.5 at concentrations as low as 6.6 μg/m3

Conclusion

Overall, CVE following STEMI and receiving PCI was associated with long term exposure to PM2.5, measured by the mean annual concentration of PM2.5. Moreover, there was a significantly higher risk of occurrence of CVE in groups with higher exposure to PM2.5. Considering strategies associated with air pollution reduction is essential for both primary and secondary prevention of future CVE.

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