Valvular Intervention: Aortic
Impact of a Novel Nutrition Index for Predicting Mortality in low-intermediate Surgical Risk Patients With Transcatheter Aortic Valve Replacement
Mitsumasa Sudo1, Atsushi Sugiura1, Marcel Weber1, Georg Nickenig1, Sebastian Zimmer1
University Hospital Bonn, Germany1
Malnutrition is an increased prognostic risk after transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis. Recently, a simple, calculable nutrition score, which can be calculated using triglyceride, total cholesterol, and body weight (TCB index), was proposed. We investigate the clinical implication of this new nutrition score in low-intermediate surgical patients with TAVR.
In 607 low-intermediate surgical risk patients, EuroSCOREII less than 9, undergoing TAVR between January 2016 and Jun 2019 at HeartCenter Bonn, University Hospital Bonn, TCB index was calculated by simple multiplication of the serum values of triglycerides, total cholesterol, and body weight divided by 1000 before TAVR procedure. Based on the cut-off value using the receiver operating characteristic curve, patients were stratified into high or low TCB index groups.
The cut-off value of TCB index was 981. Patients with a low TCB index were associated with a significantly higher cumulative one-year all-cause mortality compared to patients with a high TCB index (18.9 % vs. 9.0 %, Log-rank p < 0.01). In the multivariable model, a low TCB index is independently associated with an increased risk of mortality (HR 1.79, 95%CI 1.05 - 3.06, p =0.04).
A novel nutrition score was associated with a worse prognosis after TAVR. Our findings could be helpful for prognostic risk assessment in patients with TAVR.