Abstract

JACC

Lots of interesting abstracts and cases were submitted for TCTAP 2022. Below are the accepted ones after a thorough review by our official reviewers. Don’t miss the opportunity to expand your knowledge and interact with authors as well as virtual participants by sharing your opinion in the comment section!

TCTAP A-075

Effects of Silver Nanoparticles in Isoproterenol-Induced Myocardial Infarction

By Wawaimuli Arozal, Edwina Monayo

Presenter

Wawaimuli Arozal

Authors

Wawaimuli Arozal1, Edwina Monayo1

Affiliation

University of Indonesia, Indonesia1
View Study Report
TCTAP A-075
Pre-Clinical/First-In-Human Studies

Effects of Silver Nanoparticles in Isoproterenol-Induced Myocardial Infarction

Wawaimuli Arozal1, Edwina Monayo1

University of Indonesia, Indonesia1

Background

Background: Preventing mitochondrial dysfunction is a crucial therapeutic approach to ameliorate injury following acute myocardial infarction. Silver nanoparticles (AgNPs) are widely used in the medical field. No research has yet investigated the effect of silver nanoparticles (AgNPs) on the protection of mitochondrial dysregulation in isoproterenol (ISO) induced myocardial infarction (MI) rats.

Methods

Methods: A total of 20 male Wistar rats were randomly divided into 4 groups. Each group consisted of five rats. AgNPs and AgNO3 were administered orally at a dose of 2.5 mg/kgBW for 14 days. MI was induced on day 13 using ISO 85 mg/kgBW subcutaneously administered twice, with the second dose administered 24 hours after the first dose. Blood and tissue samples were taken 24 hours after the last dose of ISO.

Results

Results : AgNPs showed a cardioprotective effect as seen from the decrease in biochemical markers of cardiac toxicity, namely creatine kinase isoenzymes (339 U/L Vs 118 U/L, p < 0.05) and lactate dehydrogenase (2420 U/L Vs 1820 U/L, p < 0.05). In addition, the increase in plasma and cardiac tissue MDA levels in response to ISO induction was significantly decreased. AgNPs decreased BNP levels that had been increased after acute MI induction. AgNPs caused TFAM and PGC-1α overexpression activities in post-MI heart (Tfam p < 0.05, PGC-1α, p < 0.05).

Conclusion

Conclusion: These results suggest that AgNPs have a better cardioprotective effect against mitochondrial dysregulation induced by ISO, and some of the mechanisms involved in AgNPs need to be clarified in future studies.

Leave Comments