Abstract

JACC

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TCTAP A-055

Association of Left Atrial Volume Index With N-Terminal Pro-B-Type Natriuretic Peptide Level in Heart Failure Patients With Preserved Ejection Fraction

By Shamim Chowdhury, Gobinda Kanti Paul, Mirza Md Nazrul Islam, Noor E Jabeen, Mahmood Hasan Khan, Shiblee Sadeque Shakil

Presenter

Shamim Chowdhury

Authors

Shamim Chowdhury1, Gobinda Kanti Paul2, Mirza Md Nazrul Islam2, Noor E Jabeen3, Mahmood Hasan Khan4, Shiblee Sadeque Shakil2

Affiliation

National Heart Foundation of Bangladesh, Bangladesh1, Mymensingh Medical College Hospital, Bangladesh2, United Hospital Limited, Bangladesh3, Evercare Hospital Dhaka, Bangladesh4
View Study Report
TCTAP A-055
Imaging: Non-Invasive

Association of Left Atrial Volume Index With N-Terminal Pro-B-Type Natriuretic Peptide Level in Heart Failure Patients With Preserved Ejection Fraction

Shamim Chowdhury1, Gobinda Kanti Paul2, Mirza Md Nazrul Islam2, Noor E Jabeen3, Mahmood Hasan Khan4, Shiblee Sadeque Shakil2

National Heart Foundation of Bangladesh, Bangladesh1, Mymensingh Medical College Hospital, Bangladesh2, United Hospital Limited, Bangladesh3, Evercare Hospital Dhaka, Bangladesh4

Background

Heart failure is a major public health issue with a current prevalence of over 23 million worldwide. Epidemiological studies suggest that nearly one-half of patients with heart failure have a normal ejection fraction that is now termed HFpEF.Most pathophysiologic abnormalities in patients with HFpEF are related to diastolic function. LA volume has been termed “Glycosylated hemoglobin of Diastolic dysfunction”. Natriuretic peptides are widely accepted biomarker in HFrEF patients. Nowadays, it is also considered for HFpEF patients for diagnosis & prognosis purpose.

Methods

Total 120 HFpEF patients were included after considering inclusion & exclusion criteria. Sample population were divided into two groups, Group I: HFpEF patients with LAVI less than or 34ml/m(n=77);  Group II: HFpEF patients with LAVI>34ml/m2(n==43).

Results

In this study mean NT-ProBNP value of group -I & group -II were 284(+/-24 pg/ml)and 1673(+/-119.90 pg/ml) respectively, which was statistically significant. Among the demographic & clinical parameters, NYHA class, Hypertension, Diabetes mellitus were found statistically significant.  among the choreographic parameters, LV hypertrophy, mitral inflow velocity (E/A ratio), Deceleration time, TDI derived mitral annular e'  septal velocity, E/ e' (septal ) ratio were found statistically significant. Statistically significant moderately positive correlation was observed between NT-ProBNP level & LAVI level , correlation coefficient (r=0.553,p=0.001).

Conclusion

Elevated left atrial volume index (LAVI) is associated with elevated NT-ProBNP level in HFpEF patients and LAVI can used as a marker for HFpEF patients. By means of this diagnostic tool (LAVI) we can curtail the economical burden in heart failure patients.

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