Abstract

JACC

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TCTAP A-055

Association of Left Atrial Volume Index With N-Terminal Pro-B-Type Natriuretic Peptide Level in Heart Failure Patients With Preserved Ejection Fraction

By Shamim Chowdhury, Gobinda Kanti Paul, Mirza Md Nazrul Islam, Noor E Jabeen, Mahmood Hasan Khan, Shiblee Sadeque Shakil

Presenter

Shamim Chowdhury

Authors

Shamim Chowdhury1, Gobinda Kanti Paul2, Mirza Md Nazrul Islam2, Noor E Jabeen3, Mahmood Hasan Khan4, Shiblee Sadeque Shakil2

Affiliation

National Heart Foundation Hospital & Research Institute, Bangladesh1, Mymensingh Medical College Hospital, Bangladesh2, United Hospital Limited, Bangladesh3, Delta Medical College & Hospital, Dhaka, Bangladesh4
View Study Report
TCTAP A-055
Imaging: Non-Invasive

Association of Left Atrial Volume Index With N-Terminal Pro-B-Type Natriuretic Peptide Level in Heart Failure Patients With Preserved Ejection Fraction

Shamim Chowdhury1, Gobinda Kanti Paul2, Mirza Md Nazrul Islam2, Noor E Jabeen3, Mahmood Hasan Khan4, Shiblee Sadeque Shakil2

National Heart Foundation Hospital & Research Institute, Bangladesh1, Mymensingh Medical College Hospital, Bangladesh2, United Hospital Limited, Bangladesh3, Delta Medical College & Hospital, Dhaka, Bangladesh4

Background

Heart failure is a major public health issue with a current prevalence of over 23 million worldwide. Epidemiological studies suggest that nearly one-half of patients with heart failure have a normal ejection fraction that is now termed HFpEF.Most pathophysiologic abnormalities in patients with HFpEF are related to diastolic function. LA volume has been termed ¡°Glycosylated hemoglobin of Diastolic dysfunction¡±. Natriuretic peptides are widely accepted biomarker in HFrEF patients. Nowadays, it is also considered for HFpEF patients for diagnosis & prognosis purpose.

Methods

Total 120 HFpEF patients were included after considering inclusion & exclusion criteria. Sample population were divided into two groups, Group I: HFpEF patients with LAVI less than or 34ml/m(n=77);  Group II: HFpEF patients with LAVI>34ml/m2(n==43).

Results

In this study mean NT-ProBNP value of group -I & group -II were 284(+/-24 pg/ml)and 1673(+/-119.90 pg/ml) respectively, which was statistically significant. Among the demographic & clinical parameters, NYHA class, Hypertension, Diabetes mellitus were found statistically significant.  among the choreographic parameters, LV hypertrophy, mitral inflow velocity (E/A ratio), Deceleration time, TDI derived mitral annular e'  septal velocity, E/ e' (septal ) ratio were found statistically significant. Statistically significant moderately positive correlation was observed between NT-ProBNP level & LAVI level , correlation coefficient (r=0.553,p=0.001).

Conclusion

Elevated left atrial volume index (LAVI) is associated with elevated NT-ProBNP level in HFpEF patients and LAVI can used as a marker for HFpEF patients. By means of this diagnostic tool (LAVI) we can curtail the economical burden in heart failure patients.