Abstract

JACC

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TCTAP A-047 . Presentation

Presenter

Kyu-Sun Lee

Authors

Kyu-Sun Lee1, Bon-Kwon Koo1, Seokhun Yang1, Doyeon Hwang1, Gilwoo Choi2, Joo Myung Lee3, Eun-Seok Shin4, Joon-Hyung Doh5, Chang-Wook Nam6, Hyuk-Jae Chang7, Kyung Woo Park1, Hyun-Jae Kang1, Hyo-Soo Kim1

Affiliation

Seoul National University Hospital, Korea (Republic of)1, HeartFlow, Inc., USA2, Samsung Medical Center, Korea (Republic of)3, Ulsan Medical Center, Korea (Republic of)4, Inje University Ilsan Paik Hospital, Korea (Republic of)5, Keimyung University Dongsan Medical Center, Korea (Republic of)6, Severance Hospital, Korea (Republic of)7
View Study Report
TCTAP A-047
Physiologic Lesion Assessment

Are Diabetic Patients with Above 0.8 FFR Really Safe?

Kyu-Sun Lee1, Bon-Kwon Koo1, Seokhun Yang1, Doyeon Hwang1, Gilwoo Choi2, Joo Myung Lee3, Eun-Seok Shin4, Joon-Hyung Doh5, Chang-Wook Nam6, Hyuk-Jae Chang7, Kyung Woo Park1, Hyun-Jae Kang1, Hyo-Soo Kim1

Seoul National University Hospital, Korea (Republic of)1, HeartFlow, Inc., USA2, Samsung Medical Center, Korea (Republic of)3, Ulsan Medical Center, Korea (Republic of)4, Inje University Ilsan Paik Hospital, Korea (Republic of)5, Keimyung University Dongsan Medical Center, Korea (Republic of)6, Severance Hospital, Korea (Republic of)7

Background

Fractional flow reserve (FFR) is an invasive method to determine the presence of myocardial ischemia and FFR-guided revascularization has been a standard treatment strategy for patients with coronary artery disease (CAD). Unlike functional significant lesions (FFR ≤ 0.8), the treatment strategy of deferred lesions (FFR > 0.8) is conservative medical treatment and this strategy is relatively safe and showed good clinical outcomes. However, whether deferred lesions are also as safe and have good clinical outcomes in diabetes mellitus (DM) patients is unknown. To investigate this question, we evaluate the clinical outcomes of DM patients with deferred lesions according to FFR.

Methods

This study was performed based on data of two cohort studies from the 3V FFR-FRIENDS study and institutional registry of Tsuchiura Kyodo General Hospital. Patients with CAD were measured FFR and the vessel-oriented composite outcome (VOCO) (a composite of vessel-related ischemia-driven revascularization, vessel-related myocardial infarction, or cardiac death) at 5years were evaluated according to the presence of DM and FFR values.

Results

A total of 455 patients (mean age 64.7 ± 10.2 years and male 66.7%) with 826 deferred vessels were analyzed. Deferred vessels were divided into 2 groups according to FFR; Group 1 with 0.9≤ FFR ≤ 1.0 (444 vessels) and Group 2 with 0.8< FFR < 0.9 (250 vessels). The VOCO rate is 6.9% in DM patients in Group 1 (Hazard Ratio[HR], 2.46; 95% CI 0.92-6.56, p = 0.024), and VOCO rate is 11.1% in DM patients in Group2 (Hazard Ratio [HR], 19.01; 95% CI 2.43-148.6, p = 0.005). Despite deferred lesions, Group 2 (0.8 < FFR < 0.9) showed significantly higher VOCO rate in DM patient compared to Non-DM patient.

Conclusion

 Although FFR-guided management improves clinical outcomes in patients with CAD, DM patients with borderline FFR had poor clinical outcomes. These results suggest that DM patients with borderline FFR might require more intensive therapy.

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TCTAP 2021 Virtual Apr 12, 2021
Good strategy! Congratulations on the great result!