Abstract

JACC

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TCTAP A-043 . Presentation

Presenter

Cheng-Wei Liu

Authors

Cheng-Wei Liu1, Min-I Su2

Affiliation

Tri-Service General Hospital, Taiwan1, Mackay Memorial Hospital, Taiwan2
View Study Report
TCTAP A-043
Peripheral Vascular Disease and Intervention

Neutrophil-to-Lymphocyte Ratio Associated with an Increased Risk of Mortality in Patients with Critical Limb Ischemia

Cheng-Wei Liu1, Min-I Su2

Tri-Service General Hospital, Taiwan1, Mackay Memorial Hospital, Taiwan2

Background

The neutrophil-to-lymphocyte ratio(NLR) is associated with poor prognoses in cancer and peripheral artery disease patients. Its association with mortality has not been comprehensively explored in critical limb ischemia(CLI) patients. We investigated the association between the NLR and clinical outcomes in CLI patients.

Methods

We retrospectively enrolled consecutive CLI patients between 1/1/2013 and12/31/2018. Receiver operating characteristic curve analysis determined the NLRcut-offs for study outcomes, namely, 1-year in-hospital, all-cause, cardiac-related mortality, and major adverse cardiovascular events(MACEs); and major adverse limb events(MALEs).

Results

Among 195 patients (age, 74.0 years, SD: 11.5; 51.8% male; body mass index, 23.4 kg/m2, SD: 4.2), 14.4% exhibited acute limb ischemia. After 1 year, patients with a NLR>8 had higher in-hospital mortality (21.1%vs. 3.6%, P<0.001), all-cause mortality (54.4% vs. 13.8%, P < 0.001),cardiac-related mortality (28.1% vs. 6.5%, P<0.001), MACE (29.8% vs. 13.0%,P=0.008), and MALE (28.1% vs. 13.0%, P=0.021) rates than those with a NLR<8. In multivariate logistic regression, NLR ≥8 was significantly associated with all-cause (P<0.001) andcardiac-related (adjusted HR: 5.286, 95% CI: 2.075-13.47, P<0.001)mortality, and NLR ≥6 was significantly associated with MALEs (adjusted HR: 2.804, 95% CI: 1.292-6.088,P=0.009). Each increase in the NLR increased all-cause (adjusted HR: 1.028, 95%CI: 1.008-1.049, P=0.007) and cardiac-related (adjusted HR:1.027, 95%CI:0.998-1.057, P=0.073) mortality. The NLR was not significantly associated with in-hospital mortality or MACEs.

Conclusion

CLI patients with high NLRs had significantly higher risks of 1-year all-cause and cardiac-related mortality and MALEs. The NLR can be used for prognostic prediction in these patients.

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TCTAP 2021 Virtual Apr 12, 2021
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