Abstract

JACC

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TCTAP A-003

Presenter

Hashrul Rashid

Authors

Hashrul Rashid1, Michael Michail2, Abdul Rahman Ihdayhid2, Jasmine Chan2, Nancy Khav2, Sean Tan2, Arthur Nasis2, James Cameron2, Stephen Nicholls1, Rob Gooley2

Affiliation

MonashHeart, Australia1, Monash Health and Monash University, Australia2
View Study Report
TCTAP A-003
Valvular Intervention: Aortic

Prosthesis Geometrical Predictors of Leaflet Thrombosis following Transcatheter Aortic Valve Replacement with Intra-annular Prostheses

Hashrul Rashid1, Michael Michail2, Abdul Rahman Ihdayhid2, Jasmine Chan2, Nancy Khav2, Sean Tan2, Arthur Nasis2, James Cameron2, Stephen Nicholls1, Rob Gooley2

MonashHeart, Australia1, Monash Health and Monash University, Australia2

Background

Leaflet thrombosis (LT) following transcatheter aortic valve replacement (TAVR) is a recognised entity. The association between prosthesis geometry [expansion, implant depth and commissural alignment (CA)] with LT is unclear.

Methods

Patients that received an intra-annular TAVR prosthesis and prospectively planned post-procedural computed tomography (CT) with a 320-slice scanner were included. LT, defined as at least 50% restricted leaflet motion, was assessed with a dedicated 3Mensio workstation by two experienced CT readers. Prosthesis expansion and eccentricity was measured at prosthesis inflow, annulus and outflow. Prosthesis misalignment was defined as CA, the average angle deviation between native and prosthesis leaflet commissure, greater than 30°. 

Results

Prevalence of LT was 13.7% in 117 patients [13/93 cases (14.0%) for Lotus valves and 3/24 cases (12.5%) for Sapien 3 valves]. None of the patients with LT were on anticoagulation therapy (0.0% vs 22.7%, p<0.01). Other baseline and procedural characteristics were similar in both groups. There were no differences in prosthesis area or eccentricity at any prosthesis level. Patients with LT had reduced annulus expansion (89.4±5.2% vs 97.0±4.4%, p<0.01), greater prosthesis misalignment (81.3% vs 48.5%, p=0.02) and deeper implant depths (6.3±1.7mm vs 4.3±1.5mm, p<0.01). On ROC analysis, implant depth of 5.7mm was the best cut-off for the occurrence of LT (AUC = 0.81). On multivariate analysis, predictors of LT were annulus under-expansion (Odds ratio [OR] 1.4; 95% confidence interval [CI] 1.2–1.7, p=0.03), prosthesis misalignment (OR 6.8; 95%CI 1.1–45.5, p=0.04) and implant depth (OR 1.9; 95%CI 1.1–3.2 , p=0.03). Anticoagulation therapy was a protective factor for LT (OR 0.2; 95%CI 0.1–0.4, p<0.01).

Conclusion

Geometrical prostheses predictors of LT were reduced annulus expansion, lower implant depth and greater prosthesis misalignment. Implant depth of 5.7mm was the optimal cut-off for the occurrence of LT. Anticoagulation therapy was a protective factor for LT. These factors may be important considerations during procedural planning for TAVR.

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TCTAP 2021 Virtual Apr 12, 2021
Great case study! It’s very interesting and educational.