Lots of interesting abstracts and cases were submitted for TCTAP 2025. Below are the accepted ones after a thorough review by our official reviewers. Don’t miss the opportunity to expand your knowledge and interact with authors as well as virtual participants by sharing your opinion in the comment section!
TCTAP A-068
Sex-Based Differences in Outcomes Following Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-Analysis of Propensity-Matched Studies
By Ahmad Al Othman, Sofian Zreigh, Mohammed Benhammou, Walid Guerguer, Abubaker Salahudin Mukhlif Al-Allawee, Ashraf Haidarah, Serag Almzainy, Qasim Ezeddin Shawesh, Saber Khalid, Mohamedhen Vall Nounou, Rafeeek Elmezayen, Mohammad Alzu’bi, Maram Abuajamieh, Muhiddin Drvis, Muhammed Elhadi
Presenter
Ahmad Al Othman
Authors
Ahmad Al Othman1, Sofian Zreigh2, Mohammed Benhammou3, Walid Guerguer4, Abubaker Salahudin Mukhlif Al-Allawee5, Ashraf Haidarah6, Serag Almzainy7, Qasim Ezeddin Shawesh7, Saber Khalid8, Mohamedhen Vall Nounou9, Rafeeek Elmezayen10, Mohammad Alzu’bi11, Maram Abuajamieh12, Muhiddin Drvis13, Muhammed Elhadi7
Affiliation
Near East University, Cyprus1, Yildirim Beyazit University, Turkey2, University of Oran 1, Algeria3, University of Algiers 1, Algeria4, University of Fallujah, Iraq5, West China Hospital, China6, University of Tripoli, Libya7, Benghazi University, Libya8, University of Nouakchott Al Aasriya, Mauritania9, Kafr-Elsheikh University, Egypt10, The Hashemite University, Jordan11, Cairo University, Egypt12, Ankara Yildirim Beyazit University, Turkey13
View Study Report
TCTAP A-068
Minimalist TAVR
Sex-Based Differences in Outcomes Following Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-Analysis of Propensity-Matched Studies
Ahmad Al Othman1, Sofian Zreigh2, Mohammed Benhammou3, Walid Guerguer4, Abubaker Salahudin Mukhlif Al-Allawee5, Ashraf Haidarah6, Serag Almzainy7, Qasim Ezeddin Shawesh7, Saber Khalid8, Mohamedhen Vall Nounou9, Rafeeek Elmezayen10, Mohammad Alzu’bi11, Maram Abuajamieh12, Muhiddin Drvis13, Muhammed Elhadi7
Near East University, Cyprus1, Yildirim Beyazit University, Turkey2, University of Oran 1, Algeria3, University of Algiers 1, Algeria4, University of Fallujah, Iraq5, West China Hospital, China6, University of Tripoli, Libya7, Benghazi University, Libya8, University of Nouakchott Al Aasriya, Mauritania9, Kafr-Elsheikh University, Egypt10, The Hashemite University, Jordan11, Cairo University, Egypt12, Ankara Yildirim Beyazit University, Turkey13
Background
Aortic stenosis (AS) is one of the frequent valvular diseases, particularly among the elderly, with a prevalence of 2-4 % in ages over 65 years in high-income countries. It has an impact on the hemodynamics of the heart and affects females and males equally, transcatheter aortic valve implantation(TAVI) is one of the treatment strategies for AS; both males and females have variations in the outcomes following TAVI, which is still controversial, with lacking in the existing literature propensity-matched studies (PMSs) to reduce the bias between sexes regarding of baselines characteristics, our meta-analysis analyzed several PMSs, to understand matched groups how would affect the outcomes.
Methods
An electronic search was performed on the following databases: PubMed, Scopus, Cochrane Library, and Web of Science till October 2024, including all PMSs that compared males and females who underwent TAVI, no restrictions on age, year, or types of valve devices. We analyzed the data by using R Studio version 4.3.2, Risk Ratio (RR) for dichotomous values, Mean Difference (MD) for continuous values with 95%confidence intervals (CI), a random-effect model was applied and heterogeneity was tested using the I² statistic.
Results
Nine studies were meta-analyzed, pooled 73,207 patients (36,939 in the male group and 36,268 in the female group), in-hospital, 30 days mortality showed no significant difference between females and males (RR 1.25,95% CI 0.94-1.64, p = 0.12), (RR 0.99, %95CI 0.87-1.12, p = 0.86) in respectively. However, 1-year mortality females have a lower risk than males (RR 0.78, %95 CI 0.67-0.91,p < 0.01), and cardiovascular mortality (CVM) has no significant difference among females and males (RR 0.87,%95 CI 0.56-1.35,p = 0.54). Short-term stroke, major bleeding complications, and vascular complications major demonstrated that females in higher risk than males (RR 1.35,%95 CI 1.23-1.49,p < 0.01), (RR 1.25, %95 CI 1.08-1.44,p <0.01), and (RR 1.66, %95 CI 1.36-2.02, p < 0.01) in respectively, otherwise the previous outcomes in acute kidney injury (AKI) females associated with lower risk incomparison with males (RR 0.91, %95 CI 0.83-0.99, p = 0.04), while in myocardialinfarction (MI), permanent pacemaker implantation (PPI), and procedural success no significant difference found (RR 0.96,%95 CI 0.86-1.08, p = 0.54), (RR 0.94,%95CI 0.82-1.07,p = 0.33), (RR 1.00, %95 CI 0.97-1.03,p = 0.96) in respectively.
Conclusion
Our meta-analysis reveals significant sex-based differences in outcomes following TAVI. Females are at greater risk for procedural complications, including stroke, major bleeding, and vascular events. Yet, they exhibit lower one-year mortality, and a reduced risk of acute kidney injury compared to males. These findings suggest that anatomical and physiological differences may influence procedural outcomes. Addressing these disparities requires refining procedural approaches and optimizing post-procedure care for females and males accordingly.