Lots of interesting abstracts and cases were submitted for TCTAP 2025. Below are the accepted ones after a thorough review by our official reviewers. Don’t miss the opportunity to expand your knowledge and interact with authors as well as virtual participants by sharing your opinion in the comment section!
TCTAP A-033
Endovascular Management of Multi-Vessel Coronary Disease in Patients With Diabetes Mellitus
By Bakhromkhon Alyavi, Jamol Uzokov, Djamshid Pazyiev
Presenter
Jamol Uzokov
Authors
Bakhromkhon Alyavi1, Jamol Uzokov1, Djamshid Pazyiev1
Affiliation
Republican Specialized Scientific Practical Medical Center of Therapy and Medical Rehabilitation, Uzbekistan1
View Study Report
TCTAP A-033
Multi-Vessel Disease
Endovascular Management of Multi-Vessel Coronary Disease in Patients With Diabetes Mellitus
Bakhromkhon Alyavi1, Jamol Uzokov1, Djamshid Pazyiev1
Republican Specialized Scientific Practical Medical Center of Therapy and Medical Rehabilitation, Uzbekistan1
Background
Patients with multi-vessel coronary artery disease (MVD) and diabetes mellitus (DM) present unique challenges due to diffuse atherosclerosis and increased procedural risks. The optimal approach to revascularization in this population remains debated. This study evaluates the efficacy, safety, and outcomes of endovascular interventions in patients with MVD and DM compared to non-diabetic patients.
Methods
This prospective, multicenter clinical trial included 180 patients with multi-vessel coronary artery disease, 90 of whom had concurrent diabetes mellitus. Patients were randomized to receive endovascular revascularization via percutaneous coronary intervention (PCI) using drug-eluting stents. Key outcomes included peri-procedural complications, restenosis rates at 6 and 12 months, major adverse cardiovascular events (MACE), and long-term survival. Secondary outcomes included the need for repeat revascularization and improvement in quality of life as measured by the Seattle Angina Questionnaire.
Results
A total of 178 patients successfully completed the intervention (89 with DM, 89 without DM). The overall procedural success rate was 95.5%, with no significant difference between the diabetic and non-diabetic groups (94.7% vs. 96.3%, p=0.65). However, patients with diabetes demonstrated a higher rate of in-stent restenosis at 12 months compared to non-diabetic patients (22.5% vs. 14.6%, p=0.03). The incidence of MACE was also significantly higher in the diabetic group (15.7% vs. 9.0%, p=0.04). Despite these differences, long-term survival rates were similar between the groups at 24 months (91.3% vs. 93.5%, p=0.47). Quality of life improved significantly in both groups post-revascularization, though the degree of improvement was slightly lower in diabetic patients.
Conclusion
Endovascular revascularization remains an effective treatment for multi-vessel disease in patients with diabetes mellitus, though higher restenosis and MACE rates highlight the need for improved strategies in this population. Continued refinement of endovascular techniques and adjunctive therapies may enhance outcomes for diabetic patients with complex coronary artery disease.