E-Abstract

JACC

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TCTAP A-017

Ten-Year Clinical Outcomes According to Atherosclerotic Cardiovascular Disease Risk Score From AHA/ACC in Korean Patients With Significant Coronary Artery Spasm

By Woo Jin Ahn, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Jinah Cha, Sujin Hyun, Jaeho Kang, Wonsang Chu, Soohyung Park, Cheol Ung Choi

Presenter

Sujin Hyun

Authors

Woo Jin Ahn1, Seung-Woon Rha2, Byoung Geol Choi2, Se Yeon Choi2, Jae Kyeong Byun2, Jinah Cha2, Sujin Hyun2, Jaeho Kang2, Wonsang Chu2, Soohyung Park2, Cheol Ung Choi2

Affiliation

Tongyeong Detention Center, Korea Correctional Service, Ministry of Justice, Korea (Republic of)1, Korea University Guro Hospital, Korea (Republic of)2
View Study Report
TCTAP A-017
Angiography/QCA

Ten-Year Clinical Outcomes According to Atherosclerotic Cardiovascular Disease Risk Score From AHA/ACC in Korean Patients With Significant Coronary Artery Spasm

Woo Jin Ahn1, Seung-Woon Rha2, Byoung Geol Choi2, Se Yeon Choi2, Jae Kyeong Byun2, Jinah Cha2, Sujin Hyun2, Jaeho Kang2, Wonsang Chu2, Soohyung Park2, Cheol Ung Choi2

Tongyeong Detention Center, Korea Correctional Service, Ministry of Justice, Korea (Republic of)1, Korea University Guro Hospital, Korea (Republic of)2

Background

Atherosclerotic cardiovascular disease (ASCVD) risk score is a well-known risk stratification tool for assessing cardiovascular events. However, validation studies of 10-year ASCVD risk score predicting clinical outcomes in Korean patients, especially in vasospastic angina are limited.

Methods

A total of 3,991 patients with vasospastic angina, documented by the acetylcholine (ACH) or ergonovine (ERG) provocation test. Patients were divided into four groups, based on the ASCVD risk score: <5.0% group (AS1, n=1,315), 5.0 % to 9,9% group (AS2, n=937), 10.0% to 19.9% group (AS3, n=1,079) and ≧20% group (AS4, n=660). The primary endpoint was major adverse cerebral and cardiovascular event 1 (MACCE 1), including stroke and major adverse cardiovascular event (MACE). The secondary endpoint was MACCE 2, defined as composite of MACE and recurrent angina requiring follow-up coronary angiography (CAG).

Results

10-year ASCVD risk score was well stratified from AS1 to AS4 by 1.9%, 7.4%, 14.0%, and 30.5%, respectively (P<0.001). Baseline characteristics were also well stratified, presenting worse clinical profile in AS4 than in AS1. From AS1 to AS4, increasing severity of insignificant coronary stenosis (<70%) (AS1: 45.9%, AS2: 55.2%, AS3: 63.9%, AS4: 69.4%, P<0.001) was observed. Increasing incidence of both MACCE1 and MACCE2 was demonstrated through AS1 to AS4 (MACCE1: 6.6%, 6.9%, 9.6%, 17.6%, P<0.001; MACCE2: 25.3%, 25.2%, 27.8% 36.6%, P<0.001) including stroke (3.8%, 4.3%, 7.5%, 9.5%, P<0.001) and recurrent angina (21.7%, 21.7%, 22.1%, 28.5%, P=0.022).

Conclusion

The 10-year ASCVD risk score, in addition to stratifying severity of insignificant coronary stenosis, was associated with higher risk of MACCE1 and MACCE2 in patients with significant CAS.