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ABS20190926_0003
Renal Insufficiency and Contrast Nephropathy
Correlation Between Iso-Osmolar / Low-Osmolar Contrast Exposure and Contrast Induced Nephropathy and 2-Year Outcomes After Coronary Artery Intervention
Meng-yang Du1, Jinqing Yuan2
Fuwai Hospital, China1, Fuwai hospital, China2
Background:
 This study investigated the correlation between iso-osmolar/low-osmolar contrast agents and contrast-induced nephropathy (CIN) and long-term prognosis after interventional therapy for coronary heart disease. 
Methods:
All patients who underwent interventional therapy in Fuwai Hospital in 2013 were enrolled. A total of 9903 patients were enrolled in the cohort according to the exclusion criteria. According to the type of contrast agent used, the iso-osmolar contrast group and the low-osmolar contrast group were analyzed. Correlation between Iso-osmolar contrast exposure and contrast induced nephropathy and 2-year outcomes after coronary artery intervention were analyzed.
Results:
The incidence of contrast induced nephropathy was 6.2% and 9.0% in the iso-osmolar contrast group (n=1691) and the low-osmolar contrast group (n=8212), respectively, p < 0.001. The multivariate analysis showed that the use of iso-osmolar contrast agents significantly reduced the incidence of contrast induced nephropathy compared with low-osmolar contrast agents, p < 0.001. COX regression analysis showed that the use of iso-osmolar contrast agents did not affect the incidence of 2 years all-cause mortality (p > 0.05)
Conclusion:
Compared with low-osmolar contrast agents, iso-osmolar contrast significantly reduced the incidence of contrast induced nephropathy after percutaneous coronary intervention, but had no significant effect on 2-year all-cause mortality.
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